Seeking Health

Histamine Nutrients


Size: 60 Capsules | Serving Size: 2 Capsules | Servings per Container: 30

Key Benefits and Actions

  • Enhanced with cofactor nutrients for total body histamine processing
  • Comfort and relief after eating foods high in histamine
  • Great for supporting histamine intolerance protocols 

This product is not intended to diagnose, treat, cure, or prevent any disease.

Why Histamine Nutrients Works

Your histamine pathway consists of various enzymes working together to regulate histamine metabolism. They also break down the toxic byproducts created when histamine is metabolized. These enzymes require specific nutrients to act as cofactors, enabling the enzymes to work. Though DAO is the most well-known histamine enzyme, there are others.

The HNMT and NAT2 enzymes also function to break histamine down into its byproducts. Histamine Nutrients includes DAO as well as the cofactors for the DAO, HNMT, and NAT2 enzymes. The enzymatic processing of histamine can create toxic byproducts such as ammonia, hydrogen peroxide, and acetaldehyde. These toxins must be broken down by additional enzymes, including ALDH, MAOA, and MAOB.

These enzymes require zinc, niacin, and riboflavin as cofactors. Alpha keto-glutarate also helps to support the normal breakdown of ammonia. Histamine is an excitatory compound. When levels are too high, histamine can make it difficult to fall asleep at night. By providing the nutrients needed for healthy histamine metabolism, you can finally support healthy, relaxing sleep. Now, you can support more than your DAO levels. Support your entire histamine pathway with this enhanced histamine formula!

This product is not intended to diagnose, treat, cure, or prevent any disease.


Product Information & FAQ's

Who Needs Histamine Nutrients?

Are you prone to seasonal wellness issues like sinus or skin problems? Are you struggling with sleep, headaches, or skin rashes? Do you experience these issues after consuming high-histamine foods like aged cheeses, pickles, red wine, or cured meats? These can be symptoms of histamine intolerance or improper histamine metabolism. Some people don’t produce enough diamine oxidase or DAO.

This enzyme plays essential roles in metabolizing dietary histamine from food. In addition, some people have genetic variations affecting other enzymes, such as HNMT and MAOA. These enzymes break down histamine throughout the entire body. Others may be experiencing side effects from the build-up of toxic byproducts created when histamine is metabolized.

Specific nutrients are needed to maintain normal histamine breakdown in your body. Deficiency can lead to a wide array of problems stemming from incomplete histamine metabolism. Histamine Nutrients is a comprehensive formula containing the histamine-metabolizing enzyme DAO. It includes additional histamine-processing nutrients to support total body histamine breakdown.

DAO is the most well-known enzyme for breaking down histamine. However, other enzymes also play critical roles in histamine metabolism. These enzymes require specific nutrient cofactors that are contained in Histamine Nutrients. These targeted nutrients support histamine processing throughout your entire body.

The metabolism of histamine creates toxic byproducts. These include ammonia, hydrogen peroxide, and acetaldehyde. In excess, these chemicals can cause harmful side effects and damage to your cells. The synergistic blend of nutrients found in Histamine Nutrients supports healthy histamine metabolism. It also supports the body’s normal breakdown of toxic byproducts through multiple enzymatic processes.

Other Ingredients

Vegetarian capsule (hypromellose, water, and gellan gum), microcrystalline cellulose, ascorbyl palmitate, and silica.

NOT Suitable For

Vegans and Vegetarians

Histamine Nutrients is Free Of

Eggs, Fish, Gluten, GMO, Milk, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives. 

Suggested Use

Take 2 capsules no more than 15 minutes before consumption of histamine-rich foods, or use as directed by your healthcare professional.

How To Store Histamine Nutrients

Keep tightly closed in a cool, dry place out of reach by children.

Are there any side effects when using Histamine Nutrients?

Possible side effects include, but are not limited to:

  • Skin itching or flushing (from the niacin)
  • Indigestion
  • Nausea
  • Dry Mouth
  • Headache
  • Mild insomnia
  • Nervousness

If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately and discontinue use. Each individual may react differently to any product or supplement due to lifestyle, genetics, and preexisting conditions.


Not suitable for children under 4 years of age. Children and pregnant or lactating women should consult their healthcare practitioner prior to use. This product contains an ingredient derived from porcine (pig). Avoid if allergic to pork or any other ingredient. Histamine Nutrients is NOT EFFECTIVE for symptoms of immune-related food allergies, such as peanuts, shellfish, etc., or for gluten intolerance due to sensitivity or celiac disease. DAO is not absorbed and does not have systemic activity. Histamine Nutrients does not manage or address antibody-related or IgE-related food allergies.

Niacin Flushing

This formula contains niacin. When taken on an empty stomach, a healthy response to niacin supplementation may include mild blushing, warming, or tingling of the skin. This can appear on the ears, face, arms, torso, or occasionally on the legs. Commonly referred to as a "niacin flush", this harmless response normally dissipates within an hour. It is related to niacin's role in vasodilation (widening of blood vessels). Vasodilation leads to better circulation, capillary flushing, and increased blood flow to the surface of the skin. To minimize or prevent flushing, consider taking this supplement with food or in divided doses.

Who is Histamine Nutrients intended for?

Histamine Block Plus is intended for those with sensitivities to histamine-containing foods, to help the normal breakdown of histamine and histamine byproduct processing. It may be useful for those who do not experience success with Histamine Block, due to its added cofactor nutrients for processing toxic byproducts produced from histamine breakdown and support additional enzymes in the histamine pathway.

Does Histamine Block Plus contain gluten or grains?

Histamine Block Plus is gluten-free. Histamine Block Plus does not contain grains. However, this formula contains ascorbyl palmitate and vitamin C derived from corn. Due to the processes used to manufacture the finished ingredients, the ascorbyl palmitate is free from corn proteins.

Does Histamine Nutrients contain GMOs?

Testing verifies that Histamine Nutrients is free from GMO markers.