Microbiome Labs



Size: 60 Capsules | Serving Size: 2 Capsules | Servings per Container: 30

Healthy Gut Microbiome: MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.

This product is not intended to diagnose, treat, cure, or prevent any disease.


What’s in MegaSporeBiotic™?

Healthy Gut Microbiome: MegaSporeBiotic™ is a probiotic blend of 5 Bacillus spores that have been shown to maintain healthy gut barrier and immune function. The bi-phasic life cycle of the Bacillus spores allows them to remain dormant in harsh environments until they reach more favorable environments like the human gastrointestinal tract.

Once inside the large intestine, these dormant spores can change into their active, vegetative forms and begin colonizing in the gut. This unique probiotic blend aims to RECONDITION the gut instead of reseeding with probiotic strains that cannot survive digestion or colonize the gut. Healthy Gut Microbiome: MegaSporeBiotic has quickly become a household favorite among health practitioners and consumers alike.

With the launch of MegaSporeBiotic™, Microbiome Labs completely disrupted the probiotic industry, shifting the focus from reseeding to reconditioning the gut microbiome with the help of Bacillus spores.

  • Bacillus Licheniformis
    • Produces proteases that aid protein digestion
    • Produces full spectrum of B vitamins
  • Bacillus Indicus HU36™
    • Produces carotenoids: lycopene, astaxanthin, beta-carotene, and lutein
    • Produces quinols and vitamins
  • Bacillus Subtilis HU58™
    • Produces nattokinase and vitamin K2
    • Supports healthy GALT development
  • Bacillus Clausii
    • Supports immune function
  • Bacillus Coagulans
    • Produces L+ optical form of lactic acid
    • Supports immune function

    Product Information & FAQ's

    Designed by Nature

    Healthy Gut Microbiome: MegaSporeBiotic™ is formulated with nature in mind. Found naturally in the environment for millions of years, Bacillus spores have developed a symbiotic relationship with their human host. Our ancestors derived probiotic benefits from inadvertently consuming bacillus spores on a regular basis.

    In fact, the oldest bacterial spore ever documented was 250 million years old and found inside salt crystals in Carlsbad, New Mexico. Though it sounds like science fiction, scientists were actually able to isolate and grow the 250-million-year-old spores!

    Stomach Survivor

    Bacillus spores are naturally designed to survive digestion. The reason for their inherent survivability comes from the spores’ bi-phasic life cycle. This means that the Bacillus spores can transition interchangeably from their dormant form to their active form, depending on the environment.

    In its dormant spore form, Bacillus will surround itself with an endospore, which is a tough, natural outer shell that protects it from light, heat, pressure, acid, lack of oxygen, and other environmental factors. This key feature is what allows MegaSporeBiotic™ to survive easily through digestion without the need for enteric-coated capsules.

    In fact, MegaSporeBiotic™ maintains its viability outside of its capsule and can even survive baking, up to 450°F (232°C).

    Immune Support

    Over 70% of the immune system can be found in the gut in the form of gut-associated lymphoid tissue, or GALT. Studies show that Bacillus subtilis promotes the development of GALT, which is critical to the formation of a properly functioning and robust immune system.

    MegaSporeBiotic™ also supports the immune system by stimulating Peyer’s patches, as well as Toll-like receptors, in order to improve pattern recognition, increase circulating T and B lymphocytes, and upregulate regulatory T cells.

    The end result is a healthier gut lining and a stronger immune system that is better equipped to handle unfavorable lifestyle and environmental factors that can lead to conditions like asthma, allergies, autoimmunity, and infections.

    Leaky Gut Solution

    Leaky Gut Syndrome, a condition characterized by increased intestinal permeability, has become a major problem in the United States. Some studies even suggest that leaky gut plays a pivotal, and perhaps even causal, role in the development of many chronic diseases by triggering low-grade systemic inflammation.

    On the cellular level, leaky gut is the result of disrupted tight junctions between colonocytes, creating small holes in the protective intestinal wall. These small openings allow unwanted toxins to pass through the intestinal wall directly into the bloodstream, where they can increase inflammation.

    MegaSporeBiotic™ has been shown to heal leaky gut by closing tight junctions between colonocytes, increasing the thickness of intestinal mucosa, and up-regulating secretory IgA levels that support the body’s natural defense against infections. With a published, human clinical trial showing a 60% reduction in leaky gut in just 30 days, MegaSporeBiotic™ is the most effective leaky gut solution on the market today.

    Other Ingredients

    Cellulose, vegetable capsule (cellulose and water).

    Suggested Use

    Start with 1/2 capsule or 1 full capsule with food and slowly increase to 2 capsules per day using the following protocol.

    Week 1: 1 capsule every other day

    Week 2: 1 capsule daily

    Week 3+: 2 capsules daily If 1 capsule every other day causes side effects, try starting with 1/2 capsules or even 1/4 capsule in some cases.

    Possible side effects may include abdominal cramping, loose stools, and changes in bowel movements. Though these side effects may be uncomfortable, they are a sign that the product is working! Side effects should resolve within 2-3 days.

    Why is MegaSporeBiotic™ different from other probiotics already on the market?

    MegaSporeBiotic™ is the only product with 5 pharmaceutical grade bacillus spore strains. In addition, MegaSporeBiotic™ is the first probiotic to introduce a strain that produces key nutrients in the digestive system. In this case, the nutrients produced are powerful carotenoid antioxidants.

    Carotenoids are the beneficial antioxidants found in colored fruits and vegetables. Carotenoids from dietary supplements however are poorly absorbed and most people do not eat as many colored fruits and vegetables as they should, thus supplementation with a carotenoid rich probiotic is highly important.

    These beneficial bacteria produce high levels of carotenoids right at the sight of absorption, thus allowing for optimum uptake into the body. MegaSporeBiotic™ is the first and only probiotic with such a feature.

    What is a probiotic?

    • Probiotics are the fastest growing category in the supplement industry. Recent research done by the NIH has defined probiotics by a strict criteria:
      The organism must be a normally occurring organism in the digestive tract.
    • In order to consistently trigger a healthy boost in immune function the organism must be supplemented in concentrations higher than what normally occurs in the digestive tract.
    • The organism must be able to survive in the digestive tract as well as in the environment. Interestingly enough there are almost no probiotics in the marketplace that meet all three of these criteria!

    Why doesn't MegaSporeBiotic™ contain lactobacillus or bifidobacter species of probiotic?

    Lactobacillus and Bifidobacter species do meet the first requirement according to the new probiotic criteria defined by research from the Human Microbiome Project that is run by the National Institutes for Health.

    That is they do naturally occur in the digestive tract. In fact lactobacillus and bifidobacter species are in very high concentrations in the digestive tract of humans. This is exactly why these 2 bacteria cannot meet criteria two.

    There are in excess of 20 trillion lactobacillus and bifidobacter species in the average human digestive tract. Supplements today contain100 billion strains on the high end. This is nowhere near the amount that would be necessary to stimulate the immune system. This also assumes that the bacteria will survive the digestive tract.

    Research shows that a majority of orally supplemented lactobacillus and bifidobacter species are destroyed by the conditions found in the stomach and upper digestive tract. Lastly, most lactobacillus and bifidobacter species are anaerobic organisms that are designed to live in the digestive tract.

    They don’t normally live in the environment because they are sensitive to the presence of oxygen, UV light and other chemicals found in the natural environment. This means they do not fit criteria 3 of our new definition of probiotics. Its important to note that an individual gets their initial dose of lactobacillus and bifidobacter species from their mother through birth and breast feeding.

    Later in life, orally derived probiotics must be organisms that live naturally in the environment as well at the digestive system so that exposure to these organisms are possible.

    I am currently taking a probiotic and it seems to be working just fine. Why should I switch to MegaSporeBiotic™?

    MegaSporeBiotic™ offers functions that other common probiotics do not. Effective probiotics go beyond digestive health. Effective probiotics are critical for immune function, immune stimulation, managing populations of dangerous bacteria, digestion of cholesterol, neutralizing toxins, production of key nutrients, etc. Unless your current probiotic contains high doses of several spore strains, it is not providing all these beneficial affects. Use MegaSporeBiotic™ to take complete advantage of all the functions of a true probiotic

    What spores are present in MegaSporeBiotic™?

    MegaSporeBiotic™ contains 5 pharmaceutical grade strains that each have unique function and thus contribute to the overall effectiveness of the product. Below is a brief description of each:

    Bacillus Indicus HU36™ – The first carotenoid rich probiotic strain offered to the dietary supplement market. An isolate from humans, Indicus HU36™ produces high levels of powerful carotenoids (antioxidants) at the site of absorption.

    Carotenoids do not survive the gastric system well. HU36™ however, has demonstrated the ability to survive past the stomach acid and produce the carotenoids at their site of absorption in the gut.

    This makes the carotenoids produced by HU36™ the most bioavailable supplementary carotenoids in the marketplace. HU36™ gives MegaSporeBiotic™ a function that no other probiotic formulations on the market can claim-it provides key nutrients in their most potent form.

    Bacillus Clausii – This strain is the largest selling strain of prescription probiotic in the world. For the first time, this strain is made available to the U.S. dietary supplement industry and is available exclusively to healthcare professionals.

    Bacillus Clausii is recommended for use during antibiotic treatment due to its ability to resist damage from a variety of common antibiotics. MegaSporeBiotic™ has the unique function of being a powerful supplement that can be used in adjunct with antibiotic therapy to keep the organisms balanced in the gut.

    Bacillus Subtilis HU58™ – Bacillus Subtilis has been extensively studied on a genetic and functional level. There are several probiotic products in the pharmaceutical and agricultural markets that utilize this powerful probiotic.

    One very interesting function of Bacillus Subtilis is its ability to produce nearly 12 strong antibiotics that are potent fighters of opportunistic and harmful bacteria.

    Bacillus Subtilis HU58™ offers MegaSporeBiotic™ the ability to prevent harmful bacteria growth in a variety of conditions. In addition, HU58™ produces a very healthy compound called Nattokinase. Nattokinase is secreted from vegetative cells of Bacillus subtilis and has been shown to reduce blood pressure, reduce cholesterol and reduce excessive clotting by fibrinolysis.

    Along with Nattokinase, Bacillus subtilis also produces a number of other nutrients that have systemic health benefits such as B vitamins and Vitamin K2. Bacillus subtilis HU58™ offers MegaSporeBiotic™ the important function of fighting off pathogenic bacteria and producing key nutrients in the gut itself.

    In addition, HU58™ is an extremely potent immune stimulator. It has the function of germinating in the small intestines to some degree and this offers the effect of broad-spectrum immune stimulation.

    Bacillus Licheniformis – A probiotic often found with Bacillus subtilis and other bacillus species, licheniformis has been shown to have a potent effect of preventing the growth of harmful bacteria via the production of a common antibiotic called bacitracin.

    It is also a potent immune stimulator. Another very important feature of bacillus licheniformis is its ability to produce highly effective and stable protease enzymes in the gut that assist in the digestion and absorption of proteins.

    Lastly, licheniformis also produces the whole spectrum of B vitamins in the gut including folic acid and biotin and acts as an important nutrient factory in the digestive system.

    Bacillus Coagulans – A very well studied probiotic in the spore family that has a profound effect on inflammatory conditions such as IBS and Crohn’s. Bacillus coagulans offers MegaSporebiotic™ an expanded effect of controlling these common inflammatory bowel conditions in addition to its potent immune boosting activity.

    Coagulans has the unique attribute of producing lactic acid and specifically the L+ optical isomer of lactic acid, which has been shown to have a more profound effect on immune stimulation and gut defense than the other forms of lactic acid produced by conventional probiotics.

    Coagulans is also a tremendous colonizer and thus assures proper colonization of MegaSporeBiotic™, which in turn will produce the beneficial effects required. Coagulans also plays a key role in digestion of food and absorption of nutrients. In fact,

    Coagulans can digest incoming fat to reduce the uptake of cholesterol. Coagulans adds another dimension to MegaSporeBiotic™, giving it a potent ability to fight inflammatory conditions, aid in digestion and prevent the growth of harmful bacteria.

    What are the side effects of taking a probiotic/MegaSporeBiotic™?

    None have been reported.

    Any significance of taking after a meal? What about if on an empty stomach?

    Yes. The amino acids and carbohydrates in food help the spores move from their dormant (spore state) to their active (vegetative state) form in the GI. There are tremendous immune benefits if the spores are made to germinate into their vegetative state in the upper GI itself and so taking just after a meal (10-20 mins after) is ideal.

    If a probiotic has no spot to colonize, can it cause problems until it is expelled?

    In theory, yes. The bacteria could be seen as an invading species and the body can mount an immune response to it. The response would be a pro-inflammatory innate response which can then harm other tissues in the area as well. It’s important to know that a supplemented probiotic has a place in the individuals microbiota – with bacillus spores being such universal probiotics, you can feel comfortable that they have a spot to colonize every time.

    What conditions are specific for MegaSporeBiotic™?

    Clinically, we have benefitted the following conditions and other doctors have reported major benefits in these listed conditions as well: - Crohn’S, IBS, IBD and colitis - Minor and major gastro discomfort – gas, bloating, indigestion - Acid reflux/GERD - Hashimoto’s disease - Cystic acne - Rheumatoid arthritis - Allergies, asthma, eczema, psoriasis.

    Can pets (cats & dogs) be supplemented with MegaSporeBiotic™?

    Yes, the strains are universal probiotics and are used in all types of animals and livestock throughout the world, including marine life. Take one capsule, pull it apart and sprinkle it on their food.

    Will the spores still work if you pull the pill apart and still take it?

    Absolutely. This is the preferred way to administer to children. It can be pulled apart and the powder mixed into nearly any food or drink. It is temperature stable, so it can even be mixed into hot tea, coffee or soup. There is no real taste impact of the powder.