Seeking Health

P-5-P (Pyridoxal 5-Phosphate)


Size: 100 Capsules | Serving Size: 1 Capsule | Servings per Container: 100

P-5-P (Pyridoxal 5-Phosphate): Key Benefits and Actions

  • Active, bioavailable form of vitamin B6
  • Homocysteine metabolism support
  • Supports a healthy mood
This product is not intended to diagnose, treat, cure, or prevent any disease.

Why P-5-P (Pyridoxal 5-Phosphate) Works

Foods are a primary source of vitamin B6 or pyridoxine. Healthy colonies of gut microbes also produce a large percentage of our daily requirements for pyridoxine.

Pyridoxine must be transformed into pyridoxal-5-phosphate (P-5-P) before it can bind to enzymes and carry out a host of biochemical reactions in the human body. The enzyme that facilitates the final step of the transformation into P-5-P is known as pyridoxal kinase.

Since ATP (energy) is needed for this enzyme to function, insufficient levels of ATP or energy may lead to lower P-5-P formation. Genetic variations may also slow this enzyme. If a person has both slow enzyme function and low ATP levels, their formation of P-5-P may be challenged.

These individuals may benefit from a pyridoxal-5-phosphate supplement. The active form of vitamin B6, P-5-P, is used as a coenzyme in over 140 chemical reactions. These include enzymes that facilitate detoxification, neurotransmitter function, hormone metabolism and signaling, and much more.

One of the most well-known enzymes supported by P-5-P is the CBS enzyme. This facilitates the conversion of homocysteine into cysteine that is used for making glutathione.

Lesser known is the fact that P-5-P plays a role in the AADC enzyme. The Aromatic Acid Decarboxylase enzyme regulates the production of both dopamine and serotonin. These are considered the “feel good” neurotransmitters that support a healthy mood.

While only two examples out of 140 are mentioned here, the importance of maintaining healthy levels of P-5-P cannot be understated!


Product Information & FAQ's

Who Needs P-5-P (Pyridoxal 5-Phosphate)

Vitamin B6 is an essential nutrient that supports numerous functions in your body. It’s needed to metabolize homocysteine, normalize mood, balance hormones, and help you sleep. Vitamin B6 deficiency has been associated with problems involving the menstrual cycle, heart health, and mood.

Unfortunately, many people have trouble converting food sources of vitamin B6 into its active form, known as pyridoxal 5’-phosphate or P-5-P. These individuals may benefit from P-5-P dietary supplements.

Seeking Health’s P-5-P contains a potent 25 mg of vitamin B6 (1,471% Daily Value) in the active form of P-5-P (pyridoxal 5’-phosphate).

This high-strength vitamin B6 supplement is gluten-free and ideal for those who are deficient or require higher amounts. It can be a great boost to your daily multivitamin or B-complex supplement.

Vitamin B6 is required for healthy:

  • Breakdown of amino acids, carbohydrates, and fats
  • Energy production/energy metabolism
  • Immune system function
  • Brain function
  • Central nervous system function

P-5-P pairs well with magnesium to promote healthy female menstrual cycles, neurotransmitter function, and hormone metabolism prior to menstruation. It may also support stomach comfort and digestion due to occasional nausea or morning sickness.

It can be challenging to get enough vitamin B6 from foods alone. Seeking Health’s P-5-P delivers a high-quality form of vitamin B6 in a convenient capsule. For a complete B complex containing active forms of folate and vitamin B12, consider B Complex Plus.

P-5-P (pyridoxal 5’-phosphate) is considered by many to be the best vitamin B6 form. Vitamin B6 (or pyridoxine) must have a phosphate group attached for it to bind to enzymes.

P-5-P is considered an active coenzyme form of vitamin B6. It activates over 140 different enzymatic reactions in the body. Like the other B complex vitamins, you must obtain this water-soluble vitamin daily from food. This is because your body does not make it.

  • Red blood cells and red blood cell function
  • Methylation processes
  • Many enzymatic reactions

Other Ingredients

Microcrystalline cellulose, HPMC (capsule), ascorbyl palmitate, and silica.

Hydrox-Adeno B12 Lozenges is Free Of

Eggs, Fish, Gluten, GMO, Milk, Peanuts, Shellfish, Soy, Tree Nuts, Wheat, Artificial Colors, Artificial Flavors, and Artificial Preservatives.

Suitable For

Vegans and Vegetarians

Suggested Use

Take 1 capsule daily with food or as directed by your healthcare provider.

How To Store Hydrox-Adeno B12 Lozenges

Keep closed in a cool, dry place out of reach of children.

Are there any side effects when using P-5-P?

Side effects of P-5-P may cause:

  • Nausea
  • Vomiting
  • Stomach pain
  • Loss of appetite
  • Headache
  • Tingling
  • Changes in sleep habits

If you believe that you are experiencing any adverse reactions, please see your healthcare professional immediately. Each individual may react differently to any product or supplement.

We always recommend that you consult with your healthcare professional before considering the use of P-5-P or any supplement. These side-effects are more likely if the recommended dosage is exceeded, if you are taking too high of a dose when first starting, or if taken on an empty stomach.

Always take this product with food and in divided doses throughout the day. Dr. Ben Lynch recommends starting with a small dose and only working your way up if needed.


Not suitable for children under 4 years of age. For children of any age, please speak with a qualified healthcare professional who can determine an appropriate dose or whether this product is safe for them to take.

If you are being treated for any condition or are currently taking any medications, consult with your healthcare professional before considering the use of this product.

For pregnant and breastfeeding women, please talk to your qualified healthcare professional before considering the use of this product as this product has not been tested for safety in these groups.

Who is P-5-P intended for?

P-5-P is intended for those seeking an "active" or "coenzyme" form of vitamin B6, in a potent dose. Vitamin B6 ( P-5-P) is needed for more than 100 enzyme reactions - including healthy hormone balance, magnesium absorption, and homocysteine metabolism. Especially for those who eat a mostly vegan or vegetarian diet, B6 supplementation can be very important.

Does P-5-P contain gluten or grains?

P-5-P is gluten-free. P-5-P does not contain grains. However, this formula contains ascorbyl palmitate which is derived in part from highly purified corn oil. Due to the processes used to manufacture the finished ingredients, the final product is free from corn proteins.

Is P-5-P free from GMOs?

Testing confirms that P-5-P is free from GMO markers.